Acetophenones with selective antimycobacterial activity
نویسندگان
چکیده
منابع مشابه
Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity
Tuberculosis (TB) is still one of the major causes of bacterial infections and mortality in the world. In 1944, streptomycin was introduced as a first antibiotic remedy to cure TB effectively. After that, in the 1940s and 50s, with the introduction of pyrazinamide (PZA), rifampicin (RIF), isoniazid (INH), ethambutol and streptomycin as well as cocktail-drug treatment of tuberculosis, a cure for...
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A series of eighteen novel esters of salicylanilides with benzenesulfonic acid were designed, synthesized and characterized by IR, ¹H-NMR and ¹³C-NMR. They were evaluated in vitro as potential antimycobacterial agents towards Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii. In general, the minimum inhibitory concentrations range from 1 to 500 µmol/L. Th...
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The novel photoactive ruthenium(ii) complex cis-[Ru(bpy)2(INH)2][PF6]2 (1·2PF6, INH = isoniazid) was designed to incorporate the anti-tuberculosis drug, isoniazid, that could be released from the Ru(ii) cage by photoactivation with visible light. In aqueous solution, 1 rapidly released two equivalents of isoniazid and formed the photoproduct cis-[Ru(bpy)2(H2O)2]2+ upon irradiation with 465 nm b...
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OBJECTIVES Bacteriocins (Bcn) are natural peptides that are secreted by several taxonomically distant bacteria and exert bactericidal activity against other bacterial species. Their capacity to inhibit growth of virulent Mycobacterium tuberculosis H37Rv was evaluated in this study. METHODS Five different Bcn were isolated and purified from bacterial culture supernatants, their amino acid sequ...
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Mycobacterium tuberculosis causes widespread, persistent infection, often residing in macrophages that neither sterilize the bacilli nor allow them to cause disease. How macrophages restrict growth of pathogens is one of many aspects of human phagocyte biology whose study relies largely on macrophages differentiated from monocytes in vitro. However, such cells fail to recapitulate the phenotype...
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ژورنال
عنوان ژورنال: Letters in Applied Microbiology
سال: 2005
ISSN: 0266-8254,1365-2673
DOI: 10.1111/j.1472-765x.2005.01657.x